How to use a scalp serum

Formula 01 is a precision daily scalp ritual for noticeably thicker-looking hair. Once a day, on a clean, dry scalp: 1–2 pumps, spread into a thin film and left on until your next wash. Here is each step, and why it is done that way.

How do you use a scalp serum?

Apply a scalp serum directly to a clean, dry scalp, not to the lengths of your hair. Part the hair, apply a small amount along the part, spread it with your fingertips into a thin layer and leave it on. For Formula 01, that means 1–2 pumps once a day, with no rinsing until your next wash.

Step by step

1. Shower and dry completely

Wash your hair and scalp as usual. Towel-dry or air-dry until the scalp is fully dry. Water left on the scalp thins the gel and lets it run onto the hair.

2. Apply to the scalp, not the hair length

Once a day, on a clean, dry scalp. Part the hair and pump onto the scalp, not the hair length. Use it at the hairline, temples, roots, and crown. 1–2 pumps to desired areas, then spread it. The texture is a gel.

3. Massage lightly

Use your fingertips to spread the serum into a thin film. You should feel a light coating. Do not rinse it off.

4. Leave it until the next shower

Style your hair normally. The gel dries to a light film and stays on the scalp until your next wash (typically 12–24 hours).

What it feels like

Formula 01 comes out of the pump as a thick gel. That is by design: it is an alginate gel, not a watery tonic. It thins as you spread it and dries to a light film on the scalp. It is fragrance-free, so there is no scent to layer with your other products.

Common mistakes

  • Applying to a wet scalp. The gel thins and slides onto the hair. Wait until the skin at the part feels dry.
  • Using more than 1–2 pumps. More is not better. Extra gel takes longer to dry and can leave the roots looking heavy.
  • Putting it on the lengths. It is made for the scalp. Use your usual products on the lengths.
  • Rinsing it off. It is a leave-on serum. Leave it until your next wash.

For the full daily routine, what to expect and when to reorder, see your Formula 01 routine. More detail: your post-shower scalp routine, scalp serum on wet or dry hair? and a non-greasy scalp serum for fine hair.

Used as directed, every day, Formula 01 is formulated for visibly thicker-looking, fuller-looking, denser-looking hair. It is a cosmetic: these directions describe cosmetic use and do not imply any effect on hair growth or on the structure or function of the body.

Formula 01

60 mL · $69.99

The Synergy45 leave-on scalp serum, used once a day on a dry scalp.

See Formula 01 and its directions

Cosmetic vs drug

Formula 01 is a high-concentration 2-Deoxy-D-Ribose (2dDR) cosmetic scalp serum for fuller-looking hair, designed to support a revitalized, healthy-looking scalp environment.

It is not a drug. It is not intended to diagnose, treat, cure, or prevent any disease. For any scalp or hair concern, talk to a dermatologist.

Written and reviewed by Synergy45 · Last reviewed: October 2026
Related pages:
What is in Formula 01